Dr. Richard Londraville

Dr. Richard Londraville

Title: Professor
Dept/Program: Biology
Office: ASEC C312
Phone: 330-972-7151
Fax: 330-972-8445
Email: londraville@uakron.edu
Website: http://blogs.uakron.edu/londraville/


I'm a fish guy—I study how fish do what they do. I'm also a fat guy—I'm interested in what cells and organisms do with fat. Finally, I'm a temperature guy—I spend time thinking about how temperature affects cell function.For the past 15 years or so, we have focused on the hormone leptin. Leptin is famous for being the ‘fat control’ hormone in humans, and it has received LOTS of scientific attention (~50,000 studies). Our assertion is that we don’t know enough about how leptin evolved-and that by studying its evolutionary history, we will have a better understanding of how it works in humans. We have spent most of our time studying leptin in zebrafish (with Qin Liu), but also have studies in lizards (with Peter Niewiarowski), birds (with Joel Duff and Jeremy Prokop), and whales (with Hope Ball and Joel Duff). We use lots of molecular techniques, including CRISPr, qPCR, next-generation sequencing, bioinformatic analyses, and protein expression techniques.

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1994 Ph.D. University of Maine, Orono

Selected Publications

Londraville Richard L., Tuttle Matthew, Liu Qin, Andronowski Janna M. 2022. Endospanin is a candidate for regulating leptin sensitivity. Front. Physiol. 12:2307 https://www.frontiersin.org/article/10.3389/fphys.2021.786299 

Buo C, Taylor E , Dayal P , Bartles J, Christman K & Londraville RL. 2020. Spatial mapping influences navigation in Entomacrodus striatus.  Mar Fr Water Behav Physiol. https://doi.org/10.1080/10236244.2020.1785878

Cohn E, Cole P, Haymaker A, Garner AM, Londraville RL. 2020. Response to underwater laser pointer in the Orange-finned Anemonefish Amphiprion chrysopterus and three-spot damselfish Dascyllus trimaculatus. J Fish Biol.  96:274-277. https://doi.org/10.1111/jfb.14192

Tuttle M, Dalman MR, Liu Q, Londraville RL. 2019. Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) PeerJ 7:e6848

R.L. Londraville, Prokop J. W., Duff R. J., Liu Q., Tuttle M. 2017. On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin. Front. Endocrin.  8:58.

H. C. Ball, R. L. Londraville, J. W. Prokop, J. C. George, R. S. Suydam, C. Vinyard, J. G. M. Thewissen, R. J. Duff 2017. Beyond thermoregulation:metabolic function of cetacean blubber in migrating bowhead and beluga whales. J. Comp. Physiol. B.  Jan;187(1):235-252. doi: 10.1007/s00360-016-1029-6. Epub 2016 Aug 29.doi:10.1007/s00360-016-1029-6 [Epub ahead of print]. Aug 29.

Bhattarai S1, Sochacka-Marlowe A1, Crutchfield G1, Khan R1, Londraville R1, Liu Q2. 2016. Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous systemGene Expr Patterns. 2016 May;21(1):41-53. doi: 10.1016/j.gep.2016.06.004. Epub 2016 Jun 27.

Ball HC1, Stavarz MOldaker JUsip SLondraville RLGeorge JCThewissen JGDuff RJ. 2015. Seasonal and ontogenetic variation in subcutaneous adipose of the bowhead whale (Balaena mysticetus). Anat Rec (Hoboken).  298(8) 1416-1423.

Dores RM1, Londraville RL2, Prokop J2, Davis P2, Dewey N2, Lesinski N2. 2014. Molecular evolution of GPCRs: Melanocortin/melanocortin receptors. J Mol Endocrinol. 2014 Jun;52(3):T29-42. doi: 10.1530/JME-14-0050.

Prokop JW1, Schmidt C2, Gasper D2, Duff RJ2, Milsted A2, Ohkubo T3, Ball HC2, Shawkey MD2, Mays HL Jr4, Cogburn LA5, Londraville RL2. 2014. Discovery of the elusive leptin in birds: identification of several ‘missing links’ in the evolution of leptin and its receptor. PLoS One. 2014 Mar 24;9(3):e92751. doi: 10.1371/journal.pone.0092751. eCollection 2014.

Londraville RL1, Macotela Y2, Duff RJ3, Easterling MR4, Liu Q3, Crespi EJ4. 2014. Comparative endocrinology of leptin: assessing function in a phylogenetic contextGen Comp Endocrinol. 2014 Jul 1;203:146-57. doi: 10.1016/j.ygcen.2014.02.002. Epub 2014 Feb 11.

Dalman MR, Liu Q, King MD, Bagatto B and Londraville RL (2013) Leptin expression affects metabolic rate in zebrafish embryos (D. rerio)Front. Physiol4:160. doi: 10.3389/fphys.2013.00160

Ball, H.C., Holmes, R.K., Londraville, R.L. Thewissen, J.G.M., Duff, R.J. 2013. Leptin in Whales: Validation and measurement of mRNA expression by absolute quantitative real-time PCR. PLOS One. 8(1) e542771-11.

Prokop, J.W., R.J. Duff, H.C. Ball, D.L. Copeland, R.L. Londraville. 2012. Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides 38:326-336

Chen, Y., Londraville, R.L., Brickner, S., El-Shaar, L., Fankhauser, K., Dearth, C., Fulton, L. Sochacka, A., Bhattarai, S., Marrs, J.A., Liu, Q., 2012. Protocadherin-17 function in zebrafish retinal development. Dev. Neurobiol.  Aug 28 doi: 10.1002/dneu.22053

Q. Liu, M. Dalman, Y. Chen, M. Akhter, S. Brahmandam, Y. Patel, J. Lowe, M. Thakkar, A. Gregory, D. Phelps, C. Riley, and R.L. Londraville. 2012. Knockdown of leptin A expression dramatically alters zebrafish development. Gen. Comp. Endocrinol.  178 (3) 562-572.

D. L. Copeland, R.J. Duff, Q. Liu, J. Prokop, and R.L. Londraville. 2011. Leptin in Teleost Fishes: An Argument for Comparative Study. Front. Aquat. Physiol. June 2011 Vol 2 Article 26

R.L. Londraville and Niewiarowski, P.H. 2010. Leptin signaling systems in reptiles and amphibians. In: Leptin in Non-Mammalian Vertebrates. Ed. by M. Paolucci. Published by Research Signpost, Kerala, India.

Q. Liu, Chen, Y. Copeland, D. Ball H., Duff, R.J., Rockich, B., Londraville, RL. 2009. Expression of leptin receptor gene in developing and adult zebrafishGen. Comp. Endocrinol. Available online 11/24/09. doi:10.1016/j.ygcen.2009.11.015

Heflin, B., Young, L., and R. Londraville. 2009.  Short-term cycling of skin colouration in the blackspotted rockskipper Entomacrodus striatus.  J. Fish Biol.  74: 1635-1641. Published Online: Apr 27 2009
DOI: 10.1111/j.1095-8649.2009.02200.

Jury, D.R., Kaveti, S., Duan, Z-H, Willard, B., Kinter, M. and R. Londraville. 2008. Effects of calorie restriction on  the zebrafish proteome. Comp. Biochem. Physiol. D. 3:275-282.  http://dx.doi.org/10.1016/j.cbd.2008.07.003

Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G.  Fatkins. 2008. Cadherin-6 function in zebrafish retinal development. Develop. Neurobiol. Published  online May 27 2008.

Liu, B., R.J. Duff, R. L. Londraville, J.A. Marrs and Q. Liu. 2007.  Cloning and expression analysis of cadherin 7 I  n the central nervous system of the embryonic zebrafish.  Gene Express. Patterns 7(1-2) 15-22 .

Spanovich, S., Niewiarowski, P.H., and R. L. Londraville. 2006. Seasonal effects on circulating leptin in the lizard Sceloporus undulatus from two populations.  Comp. Biochem. Physiol. B 143: 507-513.

Crockett, E.L. and R. L. Londraville. 2005.  Temperature.  In: The Physiology of Fishes 3rd Edition.  CRC Press.

Liu Q, and R. L. Londraville. 2003.  Using adult zebrafish visual system to study cadherin-2 expression during  central nervous system regeneration.  Methods Cell Sci. 00:1-8.

Tschantz, D.R., E.L. Crockett, P.H. Niewiarowski, and R.L. Londraville. 2002.  Cold acclimation strategy is highly  variable among the sunfishes (Centrarchidae)  Physiol. Biochem. Zool. 75:544-556.

R. L. Londraville and C.S. Duvall.  2002.  Murine leptin injections increase intracellular fat metabolism in green sunfish (Lepomis cyanellus)  Gen. and Comp Endocrin.  129:56-62.

Liu Q., R.L. Londraville, E. Azodi, S.G. Babb, C. Chiappini, J.A. Marrs, and P. A. Raymond. 2002.  Up-Regulation of Cadherin-2 and Cadherin-4 in Regenerating Visual Structures of Adult Zebrafish.  Experimental Neurology 177:396-406

R.L. Londraville, T. D. Cramer, J.P.C. Franck, A. Tullis, and B.A. Block. 2000.  Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans).  Comp. Biochem. Physiol. B 127:223-233.

Johnson, R.M.,  T.M. Johnson, and R.L. Londraville. 2000.  Evidence for leptin expression in fishes. J. Exp. Zool.  286(7):718-724

 Niewiarowski, P.H., M.L. Balk, and R.L. Londraville. 2000. Murine leptin injection raises metabolic rate in an ectotherm. J. Exp. Biol.  203 (2):295-300